88例SARS密切接触者流行病学调查

Epidemiological study on 88 SARS-contacting persons

目的 探讨SARS密切接触者中是否有隐性感染者及评估防制措施的落实情况。方法 对广元市 88名SARS患者密切接触者进行随访 ,用“SARS病例密切接触者调查问卷”调查密切接触者的人口学特征、接触情况、防护情况及身体状况 ,用酶联免疫双抗原夹心法检测血清中特异性SARS冠状病毒总抗体水平。结果 4名医务工作者检出SARS病毒总抗体阳性 ,阳性率 4 5 % ;密切接触者的个人综合防护率为 14 8% ;医务防疫人员在国家将SARS纳入法定传染病管理前后 ,个人综合防护率有显著提高 (R控制前 =9 5 % ;R控制后 =2 9 1% ,P <0 0 5 )。结论 SABS密切接触者中存在隐性感染者 ;及早采取综合防制措施可有效控制SARS的流行 ;

Objective To study whether there were sub-clinical SARS infection among persons who ever contacted with SARS patients,and to evaluate fulfillment of control measures.Methods 88 closed contact persons were followed up.They were investigated with questionnaire about general demography characters,contact degree with SARS patients,personal protection measures and their health status.ELASA test was carried out to detect sera total antibody level of SARS corona-virus.Results Four closed contact persons were SARS antibody positive and the positive rate was 4.5%.The rate of personal overall protection was 14.8%,which of high-risk hygiene workers before April 13 was significant higher than the rate after that time (R before control=9.5%;R after control=29.1%;P<0.05),when SARS was controlled as an infectious disease defined legally by the Ministry of Public Health.Conclusion There were sub-clinical infection with SARS corona-virus among closed contact persons.Carrying out overall protection measures at early period when SARS imported in Guangyuan city,could effectively control SARS spreading in Guangyuan city and Sichuan province.Major problems for controlling SARS transmission in the future were to strengthen personal overall protection measures and control hospital infection.