诺瓦克样病毒抗体水平及其相关因素研究

Serum antibodies against Norwalk-like viruses and concerned factors

目的 了解某军校学员诺瓦克样病毒抗体水平 ,同时调查分析与血型、入学前家庭所在地等的关系。方法 利用酶联免疫吸附试验检测血清中的诺瓦克样病毒rNV、rMX和r387特异性IgG抗体水平。结果 rNV、rMX和r387IgG抗体总检出率分别为 88 9% ,5 4 1%和 90 0 %。其中rMX抗体阳性率不同血型之间存在显著性差异 (P<0 0 5 ) ,以O型抗体阳性率最高 6 2 5 % (115 / 184 ) ,B型最低 4 9 1% (16 0 / 2 16 ) ,而rNV和r387抗体阳性率未见显著性差异。不同入学前家庭所在地 3种抗体阳性率均有显著性差异 ,其中以农村籍学员抗体阳性率最高 ,城市最低。结论 该军校人群中诺瓦克样病毒感染普遍 。

Objective To investigate serum antibodies against Norwalk-like viruses of a military university and the concerned factors ;such as blood type and the family locus before enrolling.Methods Serum specimens are tested by an indirect enzyme-linked immunosorbent assay(ELISA) for specific IgG respectively to rNV,rMX and r387.Results The seroprevalence is 88.9% for rNV,54.1% for rMX and 90.0% for r387.There is significant difference between blood types for rMX of which the type O prevalence is the highest(62.5%),and the type B is the lowest(49.1%).And there is significant difference between the family locus before enrolling for rNV,rMX and r387.Conclusion The data indicates that infections of Norwalk-like viruses in the military university are very common.And blood type and family locus before enrolling may be the risk factors of the serum antibodies of Norwalk-like viruses.