果胶对大鼠血脂及抗氧化功能的影响

Effect of pectin on rat's blood lipids and antioxidant capacity

目的 研究不同剂量的果胶对高脂血症大鼠的血脂及抗氧化功能的影响。方法 根据血清总胆固醇和体重将Wistar大鼠随机分为 5组 ,以正常饲料和高脂饲料为对照组 ,低、中、高剂量组分别喂饲不同水平 (5 % ,10 % ,2 0 % )的果胶 ,测定血脂和抗氧化功能指标。结果 各剂量水平果胶均可显著降低大鼠的摄食 ;同高脂对照组相比 ,中剂量和高剂量组大鼠血清总胆固醇 (TC)、甘油三脂 (TG)水平显著降低 ,且中剂量组血清高密度脂蛋白胆固醇 (HDL-C)水平提高 ,各剂量组血清丙二醛 (MDA)水平均降低 ,低剂量组和中剂量组的血清超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH -Px)水平无显著性变化。结论 果胶对高脂血症大鼠的血脂有调节作用 ,并且降低其体内的脂质过氧化水平 ;

Objective To investigate the regulating effects of pectin on lowering blood lipids and antioxidation in the hypercholesterolemic rats.Methods Adult male Wistar rats were divided into five groups,ten rats per group.As the control group,normal diet group and high-fat diet group were fed either the normal diet or high-cholesterol diet.The low,middle and high dose groups were given one of the diets incorporated pectin at the different level of 5%,10%,10% or 20% respectively,the experiment lasted one month.Results Pectin affected the feed intake of the experimental rats.The serum levels of TC,TG in the middle and high dose groups were significantly lower and HDL-C in the middle dose grpoup higher than high-fat group;The level of MDA was significantly lower in all three experimental groups than high-fat group,there were no different changes of activities of SOD and GSH-Px in the low and middle dose groups compared with high-fat group.Conclusion Pectin could decrease the blood lipids level and peroxidative status.High dose pectin was harmful to rat' health.