膳食钙降低饮食诱导肥胖大鼠体重的机制

Mechanism of dietary calcium on reducing body weight of obese rats induced by diets

目的 研究膳食钙对饮食诱导肥胖大鼠的治疗作用及其机制。方法 以雄性Wistar大鼠为实验对象 ,用高脂饮食诱导大鼠肥胖模型。将肥胖大鼠按体重随机分为 4组 :A组为基础饲料组 ,B组为高脂低钙组 (含 0 2 5 %钙 ) ,C组为高脂正常钙组 (含 0 5 %钙 ) ,D组为高脂高钙组 (含 1%钙 )。于第 10周末处死动物 ,计算脂 /体比 ,测定血糖、血脂和激素水平。结果 高钙膳食降低饮食诱导肥胖大鼠的体重和体脂含量 ,改善血脂代谢紊乱状态和胰岛素抵抗 ;膳食高钙通过促进瘦素分泌 ,降低神经肽Y分泌 ,升高血中游离T3和生长激素水平 ,起到降低饮食诱导肥胖大鼠体重和体脂含量的作用。结论 高钙膳食可以影响血中瘦素、神经肽Y、T3和生长激的水平 。

Objective To observe the effect of dietary calcium on obese rat and study the mechanism.Methods Obses rat model was induced by high fat diet.Then obese rats were randomly divided into four groups and were respectively fed with different diets(basic diets,high fat diet with 0 25% calcium,high fat diet with 0 5% calcium,high fat diet with 1% calcium)for 10 weeks.At the end of experiment,the rats were sacrificed.The blood glucose,serum lipids and hormones were measured.Results High dietary calcium reduced the weight and fat pad of obese rats,decreased serum cholesterol,triglyceride,serum insulin and plasma neuropeptide Y,and increased serum leptin,serum FT3 and growth hormone.Conclusion High dietary calcium affected the levels of serum leptin,plasma neuropeptide Y,serum FT3 and growth hormone,consequently reduced the weight of obses rats induced by high fat diet.