集中式改水防治地方性砷中毒的近期效果评价

Recent efficency of water mitigation project on endemic arsenic poisoning

目的 评价集中式改水对砷暴露人群的近期防治效果。方法 选择内蒙古包头市缸房营村饮水型砷中毒高发病区 ,观察改水前和集中式改水 1年后砷暴露人群的皮肤损伤恢复情况 ;原子吸收分光光度法测定尿总砷和形态砷含量 ;ELISA方法测定尿 8-羟基 - 2′ -脱氧鸟苷 ( 8-OH -dG)含量。结果 集中式改水 1年后砷暴露人群的皮肤损伤有明显恢复 ;尿总砷和形态砷含量、尿 8-OH -dG含量均明显降低。结论 在饮水型中毒病区集中式改水除砷是一种有效的干预措施。改水 1年使砷暴露人群的皮肤损伤明显改善 。

Objective To compare the DNA oxidative injuries of people exposed to arsenic in drinking water before and after water mitigation project for one year.Methods People exposed to arsenic in drinking water were selected in Gangfangying village,inner Mongolia.The skin lesions induced by arsenic were compared;The concentrations of total arsenic,inorganic arsenic,monomethylarsonic acid and dimethylarsinic acid of urine,the levels of urine 8-hydroxy-2'-deoxyguanosine(8-OH-dG)were measured by AAS and ELISA,respectively.Results The skin lesions induced by arsenic were improved markedly after water mitigation project for one year;The concentrations of total arsenic,inorganic arsenic,monomethylarsonic acid,dimethylarsinic acid of urine and the levels of urine 8-OH-dG all decreased significantly.Conclusion Water mitigation project was an effective intervention method in endmic arsenic areas.Skin lesions of people exposed to arsenic in drinking water were improved and their DNA oxidative injuries decreased after one year water mitigation.