免疫因素与男性不育的相关性

Correlation between immune factor and male infertility

目的 :观察不育男性血清抗精子抗体 (AsAb) ,抗心磷脂抗体 (ACA) ,抗弓形虫抗体与精液各指标之间的关系 ,揭示免疫因素与不育症的相关性及致病机制 .方法 :用ELISA(Enzyme linkedimmunosorbentassay)法测定 2 86例男性不育患者及 198例正常生育者血清的AsAb ,ACA ,抗弓形虫抗体并常规检测精液的各项指标 .结果 :不育者血清中的AsAb ,ACA ,抗弓形虫抗体阳性率 (2 9.4 % ,18.2 % ,17.1% )明显高于正常生育组 (9.0 % ,7.0 % ,9.0 % ) ,P <0 .0 1;不育患者血清AsAb水平变化能导致精子的活动力明显下降 ,呈显著性正相关 ,P<0 .0 1.结论 :AsAb与男性不育有密切关系 ,可引起精子活率、活力明显下降 ,但对精子密度及液化无明显影响 .

AIM: To examine the relationship between antisperm antibody (AsAb), anticardiolipin antibody (ACA) and anti-toxoplasma antibody in the sera of inferlile of males, and other indexes of semen and to study the correlation and mechanism of AsAb, ACA, anti-toxoplasma antibody and infertility. METHODS: AsAb, ACA and anti-toxoplasma antibody in sera from 286 cases of male infertile patients and 198 normal persons were measured with enzyme-linked immunosorbent assay (ELISA) and other indexes of semen were also detected. RESULTS: The positive rate of AsAb (29.4%), ACA (18.2%) and anti-toxoplasma antibody (17.1%) in the sera of infertile patients was significantly higher than that of normal controls (9.0%, 7.0% and 9.0%, respectively, P<0.01). The change of AsAb level could cause a remarkable decrease of sperm activity and a significant positive correlation was found (P<0.01). CONCLUSION: AsAb is closely related to male infertility and may lead to a remarkable decrease of sperm activity, but it does not significantly affect sperm density and liquidization.