摘要
本实验观察家兔喂饲胱氨酸后的不同时期内,血浆PGI2和TXA2的动态变化特点,并对血胆固醇,胱氨酸水平和动脉壁脂质斑块形成程度进行比较,目的在于探讨胱氨酸致动脉粥样硬化的可能机制,并为临床防治冠心病提供帮助。
This experiment tock 20 rabbits randomly
divded into experimental (feeding with cystins)
and control group. Drawing blood for biochem-
icae and radioimmunoassay test in pre-experime-
ntal and 4th, 8th, 12th Week days after feeding.
The result discovered that the contents of
serum cystine, platelet aggregation and plasma
TXA_2 levels increased in the experimental
group more than that of thc contolled rabbits,
but plasma PGI_2 decreased. While the contents
of total cholesterol was not Changed. Athero-
scleretic plazues in the aorta was also rema-
rkable incrensed. There were foamy cells piled
up and by microscopic analysis.
According to results of above metioned, we
conclude that high-cystinemia may lead to
atherosclerosis because of destroyed aorta Wall,
activated platelet function and inbalance of
PGI_2-TXA_2, but not releted to lipidemia
levels.
出处
《广东医学》
CAS
CSCD
1993年第3期153-154,共2页
Guangdong Medical Journal
