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噬菌体抗体库技术及其研究进展

Introduction to technology of phage antibody library and its research progress
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作者 海岗 才学鹏
机构地区 中国农业科学院兰州兽医研究所
出处 《中国兽医科技》 CAS CSCD 北大核心 2004年第9期40-45,共6页 Chinese Journal of Veterinary Science and Technology
基金 国家重点基础研究发展规划 (973)项目 (G19990 119)
关键词 分子生物学 噬菌体抗体库技术 噬茵体展示技术系统 抗体可变区基因 载体 表达
分类号 Q78 [生物学—分子生物学] Q939.48 [生物学—微生物学]
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参考文献25

  • 1[1]Pereira S,van Belle P, Eleder D,et al. Combinatorial antibodies against human malignant melanoma [J]. Immunology,1997,16(1):11-15.
  • 2李有全,刘光远,白启,邱昌庆.基因工程抗体的研究进展[J].中国兽医科技,2003,33(6):36-41. 被引量：3
  • 3[3]Ward E S. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli [J]. Nature,1989,341:544.
  • 4[4]Huse W D .Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda [J]. Science,1989,246:1275.
  • 5[5]Ochi A. Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production [J].Nature,1983,302:340.
  • 6王学,徐静.人噬菌体抗体库的有效表位多样性[J].国外医学（分子生物学分册）,1996,18(6):252-255. 被引量：2
  • 7[7]Barbas C F .Assembly of combinatorial antibody libraries on phage surfaces [J]. Proc Natl Acad Sci USA,1991,88:7978.
  • 8[8]Cwirla S E, Peters E A, Barret R W, et al. Peptides on phage: a vast library of peptides for identifying ligands [J]. Proc Natl Acad Sci USA,1990,87:6378-6382.
  • 9[9]McCafferty J, Griffiths A D, Winter G, et al. Phage antibodies: filamentous phage displaying antibody variable domains [J]. Nature,1990,348:552-554.
  • 10[10]Scott J K, Smith G P. Searching for peptide ligands with an epitope library [J]. Science,1990,249:386-390.

二级参考文献27

  • 1Sharon J, Gefer M L, Morrison, etal. Expression of a VH Cк chimaeric protein in mouse myeloma cells [J]. Nature,(24): 364-367.
  • 2Bouliance G L, Hozumi N, Shulwan M J, et al. Production of functional chimeric mouse/human antibody [J]. Nature, 1984, 312(13) : 643-646.
  • 3Ishida T, Tmai K. The expression technology of chimeric and humanized antibodies[J].Nippon Rinsho, 2002, 60(3): 439-444.
  • 4Pluck A . Mono and bivalent antibody fragment produced in E. coli: engineering, folding, and antigen binding [J]. Immunol Rev,1992, 130(2): 51-58.
  • 5Holliper P, Prospero T, Winter G. "Diabodies": small bivalent and bispecific diabody fragments[J]. Proc Natl Acad Sci USA,1993, 90: 6444-6448.
  • 6Burton D R . Human and mouse monoclonal antibodies by repertoire cloning [J].Tibtech, 1991, 9. 169-174.
  • 7Winter G , Griffiths A D. Making antibody by phage display technology [J]. Ann Rev Immunol, 1994, 12 : 433-448.
  • 8Kasmam L M, Lukowiak A A, Garczynski S F, et al. Phage display of a biological activity Bacillus thuringiensis toxin [J]. Applied and Environmental Microbiology, 1998, 64:2995-3003.
  • 9Lonberg N, Taylor L D, Harding F A, et al. Antigen-specific human antibodies from mice comprising four distinct genetic modifications[J].Nature, 1994, 368(6474): 856-859.
  • 10Neuberger M , Bruggemam M . Mice perform a human repertoire [J]. Nature,1997,386 (6620) : 25-26.

共引文献13

中国兽医科技
2004年 第9期

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