转化生长因子-α在脂溢性角化病皮损中的表达

Expression of Transforming Growth Factor-α in Skin Lesions of Seborrheic Keratosis

目的 探讨转化生长因子 α(TGF α)与脂溢性角化病 (SK )发病的关系。方法 采用免疫组化法检测 3 0份SK皮损组织和 10份正常皮肤组织中TGF α的原位表达水平。结果 SK皮损组织中有TGF α的表达 ,其阳性表达程度与正常对照组比较差异有显著性。结论 SK皮损组织中TGF α异常高表达 ,提示TGF

Objective To study the relationship between transforming growth factor-α(TGF-α) and the seborrheic keratosis(SK).Methods 30 cases of SK and 10 cases of normal skin tissue were examined by immunohistochemistry assay.Results The expressive intensity of TGF-α in the SK group was significantly higher than those in the controls.Conclusion The TGF-α overexpressed in SK tissues might play an important role in the growth and development of SK.