兰州重离子束治癌Bragg峰展宽装置参数设计

The parameter design of Spread-Out Bragg Peak device for proton beam tumor therapy in Lanzhou

针对兰州质子加速器研究装置提供的 1 2 0MeV/u1 H+离子束 ,探索了模拟退火优化算法的原理及方法 ,实现了Bragg峰展宽的剂量优化 ,讨论了质子束治癌临床上最优的Bragg峰展宽模型的选取 ,并给出了旋转式装置的参数 ,供即将在中科院近代物理所质子加速器上开展的浅层治癌等放射生物医学研究工作做参考。

Proton beams used for tumor therapy have some important advantages. Especially, the optimization of the depth-dose distribution of the proton beam in a given focus of a tumor by using a Spread-Out Peak (SOBP) technique will greatly enhance the therapeutic effects for the tumor therapy. We adopted the simulated annealing algorithm to complete the optimization process for the high energy ( 1H 120MeV/u) proton beam, which can be supplied by HIRFL, in an 11cm range of water and with 1.5mm step lengths to give a set of SOBP parameters. According to the result a typical range modulator which is rotated through the beam is designed.