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抵抗素的研究进展 被引量:1

Rsearch progress of resistin
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摘要 肥胖可以引起胰岛素抵抗 ,然而 ,其确切机制还不清楚。几年前 ,有研究发现 :脂肪细胞分泌一种独特的信号分子———抵抗素 ,它有拮抗胰岛素的作用。所以 ,当时认为抵抗素可能是肥胖引起胰岛素抵抗的关键所在。但是 ,随着研究的深入 ,越来越多的实验对此提出异议 ,认为抵抗素并不是肥胖引起胰岛素抵抗的一种主要激素。
出处 《国外医学(儿科学分册)》 2004年第5期263-265,共3页 Foreign Medical Sciences(Section of Pediatrics)
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  • 1Hotamisligil GS.The irresistible biology of resistin[J].J Clin Inves,2003,111(2):173-174.
  • 2Steppan CM,Bailey ST,Bhat S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409(6818):307-312.
  • 3Fukui Y,Motojima K.Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha[J].Diabetes Obes Metab,2002,4(5):342-345.
  • 4Fujita H,Fujishima H,Morii T,et al.Effect of metformin on adipose tissue resistin expression in db/db mice[J].Biochem Biophys Res Commun,2002,298(3):345-349.
  • 5Fasshauer M,Kein J,Neumann S,et al.Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes[J].Biochem Biophys Res Commun,2001,288(4):1027-1031.
  • 6Nogueiras R,Gualillo O,Caminos JE,et al.Regulation of resistin by gonadal,thyroid hormone,and nutritional status[J].Obes Res,2003,11(3):408-414.
  • 7Lu SC,Shieh WY,Chen CY,et al.Lipopolysaccharide increases resistin gene expnession in vivo and in vitro[J].FEBS Lett,2002,530(1-3):158-162.
  • 8Zhong Q,Lin CY,Clarbe KJ,et al.Endothelin-1 inhibits resistin secretion in 3T3-L1 adlipocytes[J].Biochem Biophys Res Commun,2002,296(2):383-387.
  • 9Steppan CM,Brown EJ,Wright CM,et al.A family of tissue-specific resistin-like molecules[J].Proc Natl Acad Sci USA,2001,98(2):502-526.
  • 10Kim KH,Lee K,Moon YS,et al.A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation[J].J Biol Chem,2001,276(6):11252-11256.

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