小剂量生长激素补充对中老年男性性功能障碍患者的影响

Effects of low dose growth hormone supplement on middle-aging male with sexual dysfunction

目的 探讨小剂量生长激素补充对中老年男性性功能障碍患者的疗效和安全性。方法 30例42-77岁有性功能障碍、血睾酮水平正常的中老年男性随机分成A、B两组。A组病人按0.04U/Kg/次,每周3次,皮下注射rhGH,连续用药3个月;B组病人先给予安慰剂1个月,然后再按A组给药方案应用rhGH 3个月。记录治疗前、后各项有关指标。结果 A、B两组应用rhGH后,每月晨间勃起次数由10.25.3次增加到19.44.8次(P<0.01);成功阴道插入次数由1.61.1次增加到3.82.2次(P<0.01);男性更年期症状总评分及性功能症状评分显著下降;IIEF-5评分显著上升;而B组患者在应用安慰剂的第1个月,各项指标均无明显变化。结论 小剂量生长激素补充可使部分中老年男性性功能显著改善,无明显副作用,但由于其是一种促进全身代谢的激素,使用仍应谨慎。

Objective To evaluate the effects of low dose growth hormone(GH) supplement on middle-agingmale with sexual dysfunction. Methods 30 patients, 42 to 77 years old, with sexual dysfunction having normalserum testosterone were randomly divided into two groups. Group A was given growth hormone subcutaneously indose of 0.04U/Kg, 3 times/week for three months. Group B was given placebo in the first month, then given GH thesame way as Group A next three months. Before and after treatment, self rating scale used by Bosphorus university,average morning erections per month, frequency of successful performed sexual intercourse per month , IIEF-5, IPSSand adverse effects were recorded. Results After given GH, the rating scores, average morning erections per month,frequency of successful performed sexual intercourse per month, IIEF-5 scores were significantly improved, whileIPSS did not change significantly. Conclusion three-month course of low dose growth hormone supplement canimprove the sexual function in middle-aging male with little adverse effect.