HLA-B_(27)抗原检测对强直性脊柱炎的诊断价值

DIAGNOSTIC VALUE OF HLA-B DETECTION OF ANKYLOSING SPONDYLETIS

自1973年Schlosstein等和Brewerton等首先发现HLA B_(27)抗原与强直性脊柱炎(AnkylosingSpondyletis,AS)呈强相关以来,国内外相继有报道证实这一见解。AS好发于青年男性,有明显的遗传倾向,主要表现为脊椎和骶髂关节疼痛,有的最后发展至脊柱强直畸形。白种人AS病人中B_(27)

Immunological Laboratory of N euroscie-nces Research Institute in Guangzhou MedicalCollege The posifive detective rate of HLA-B27from 54 patients with ankylosing spondyletis(AS) was 94. 4%, that of suspected 66 ASpatients Has 77.3%, and that of 120 healthpersons Has 0.8%. The difference betweenpatients with AS and herlthy persors wasvery obvious, P 0.001. Twenty-four of the120 patients with AS had family history(20%). The analyses of HLA-B27 wee donein another 2 families with AS, the resultsof analyses further shaw that there is a clo-sing association batween HLA-B27 and AS.The 66 of 120 patients were suspectec origi-nally, 51 patients were finally diagnosedthrough the detection of HLA-B27 and otherclinical data. These show that the detectionof HLA-B27 is a valuable diagnostic markerof AS.