摘要
应用1D和2DNMR脉冲梯度场反相技术(gCOSY,gNOESY,gHSQC,gHMBC)研究了手性抗炎药物布地奈德 -R的结构 ,并对其碳氢NMR信号进行了全归属。提出应用 1HNMR技术控制其制剂中布地奈德 -R和布地奈德
A series of1D-and2D-NMR pulse field gradient phase_cycling techniques,including gCOSY,gNOESY,gHSQC and gHMBC,were applied to the study of the structure of the chiral anti_inˉflammatory drug budesonide-R[(22R)_16α,17α_Butylidenebis(oxy)_11β,21_dihydroxy_pregna_1,4_diene_3,20_dione]and to the assignment of all its proton and carbon signals.The 1 H NMR technique is proposed for quality control of the ratio of budesonide-R to budesonide-S in budesonide products.
出处
《分析测试学报》
CAS
CSCD
北大核心
2004年第5期29-31,37,共4页
Journal of Instrumental Analysis
