摘要
大鼠(SD)16只3月龄雄性,按随机表分为激素组和对照组,激素组喂醋酸泼尼松2次/周,3个月后对两组动物胫骨中段骨代谢的指标用图象分析仪进行测算和分析。激素组与对照组比较结果:(一)骨外膜变化率,两组比较差异显著(P<0.05),其中(1)成骨细胞数量的荧光周长减少—41;(2)代表成骨细胞功能的指标骨矿化沉积率下降—29;(3)骨形成率出现明显的减少—55。(二)骨内膜变化率,上述三指标都有下降的趋势,但无显著性差异,仅有骨吸收周长增加92％。这些发现提示糖皮质激素药物对大鼠密质骨的影响主要在骨外膜,其次才波及到骨内膜,这样的影响可能与血流分布有关。
This paper deals with the effects of glucocorticord hormone (GC) on male rat bone mineral metabolism. Two groups of male SD rats were administered vehicle or prednisone acetate(4. 5mg/kg) ,twice per week for 90 days. The histomorphometric parameters of the tibial shaft cortical bone were measured and calculated. The labeling perimeter, mineral apposition rate and bone formation rate were significantly decreased in periosteal surface. Insignificant in
endosteal surface. Only resorption perimeter greatly increased. The results indicated that GC had different effects in periosteal and endosteal surface which may be associated with blood distribution in two surface.
出处
《广东医学院学报》
1993年第4期183-185,共3页
Journal of Guangdong Medical College
关键词
糖皮质激素
骨质疏松症
强的松
glucocorticord hormone
prednisone acetate
osteoporosis
trabecular bone
