正交试验优化马蔺子素-羟丙基-β环糊精包合物的制备工艺

Preparation technique of irisquinone-hydroxypropyl-β-cyciodextrin inclusion complex with orthogonal design

目的 :正交试验法优化搅拌法制备马蔺子素 羟丙基 β环糊精包合物的最佳工艺。 方法 :以载药量和收率为指标 ,考察主客分子摩尔比、乙醇浓度和搅拌速度等因素制备马蔺子素 羟丙基 β环糊精包合物的最佳制备工艺。 结果 :主客分子以 2∶1摩尔比 ,90 %乙醇作溶媒 ,搅拌法制备的马蔺子素包合物载药量为 (15 .79± 0 .2 2 ) % ,收率为 (92 .0 3± 6 .2 6 ) % ;包合物中马蔺子素溶出速率参数Td 和T50 明显地小于胶囊剂。结论 :优化工艺制备的包合物具有操作简单、适合工业化生产 。

AIM: To screen and optimize the preparation conditions of irisquinone-hydroxypropyl-β-cyclodextrin inclusion complex (Irisquinone-HP-β-CD) with stiring method. METHODS: The load-drug and recovery of irisquinone were adopted as the index, host-guest molar ratio, alcohol concentration and stiring rate as factors, have been investigated in the techniques of irisquinone-HP-β-CD. RESULTS: The load-drug and recovery of irisquinone-HP-β-CD were respective ( 15.79 ±0.22)% and ( 92.03 ±6.26)% by optimizing conditions which were host-guest molar ratio 2∶1, 90% EtOH and stiring rate 800r·min -1. At the same time, the dissolution test showed that irisquinone was faster released from inclusion complex than that from capsules and mixture dosage form. CONCLUSION: The optimizing techniques fit to prepare irisquinoe-HP-β-CD in industry.