恶性肿瘤患者化疗及生物化学治疗后淋巴细胞亚群的变化

Changes of Lymphocyte Subsets of Patients Suffered from Malignant Tumors After Treated with Chemotherapy and Biochemotherapy

目的 观察恶性肿瘤患者化疗和生物化学治疗前后淋巴细胞亚群的变化及其临床意义。方法 利用流式细胞仪测定 3 2例化疗前后和 2 6例生物化学治疗前后的淋巴细胞亚群及其活性。结果 化疗结束后 1个月患者CD2 5 + 及NK细胞较化疗前明显降低 (P <0 0 5 ) ,CD4+ 和CD8+ 细胞无明显变化 (P >0 0 5 )。化疗后应用免疫治疗组CD2 5 + 及NK细胞较化疗前明显升高 (P <0 0 1及P <0 0 5 )。结论 化疗对恶性肿瘤患者细胞免疫功能有明显抑制作用 ,化疗结束后应用生物反应调节剂对恶性肿瘤患者的细胞免疫功能有明显改善作用。

Objective To study lymphocyte subsets changes in patients with malignant tumors after chemotherapy or biochemotherapy and their clinical significance.Methods Thirty-two cases were treated with chemotherapy and twenty-six cases were treated with biochemotherapy, and lymphocyte subsets were determined by flowcytometry.Results Chemotherapy significantly decreased CD25 + and NK cells(P<0.05), while CD4 + and CD8 + cells changed little (P>05). Biochemoyherapy elevated CD25 + and NK cells (P<0.01 and P<0.05), while CD4 + and CD8 + cells remained unchanged (P>05).Conclusions Chemotherapy suppresses the activity of cell immune, and treated with biological responses modifiers to patients with malignant tumors after chemotherapy can improve their cell immunological function.