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维生素D受体研究进展 被引量：8

Vitamin D receptor and vitamin D receptor gene polymorphism research
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摘要 维生素D受体 (VitaminDreceptor ,VDR)属于类固醇类激素 ,在体内主要介导维生素D的细胞作用。其基因上存在多个多态性位点 ,并与许多疾病发生有关。本文主要介绍了VDR的结构及功能。 Vitamin D receptor(VDR) belongs to steroid hormone, it is mainly as a material of vitamin D acting on cell. There are some polymorphic loci in the VDR gene and they are associated with many diseases. The article reviews the structure and function of VDR, and its relafanship between gene polymorphisms and some diseases.
作者 郗永义 郑秀芬 叶健 霍赛虎 张健 陈帅锋
机构地区 中国人民公安大学研究生部 公安部物证鉴定中心
出处 《大连医科大学学报》 CAS 2004年第3期227-230,共4页 Journal of Dalian Medical University
关键词 维生素D 维生素D受体 骨密度 Vitamin D Vitamin D receptor bone mineral density
分类号 R341 [医药卫生—基础医学]
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参考文献19

  • 1缪应新,朱汉民,朱晓颖,甘洁民,陈淑英.上海地区汉人维生素D受体基因多态性与骨密度关系的初步分析[J].中国骨质疏松杂志,2002,8(1):20-22. 被引量：19
  • 2Morrison NA, Yeoman R, Kelly PJ, et al. Contribution of transacting factor alleles to normal physiological variability: vitamin D receptor gene polymorphisms and circulating osteocalcin[J]. Proc Natl Acad Sci USA, 1992, 89:6665-6669.
  • 3Capiati DA, Tellez-Inon MT and Boland RL. Participation of protein kinase C alpha in 1,25-dihydroxy- vitamin D3 regulation of chick myoblast proliferation and differentiation[J]. Mol Cell Endocrinol, 1999,153:39-45.
  • 4Ferrari S, Rizzoli R, Manen D,et al. Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: Interaction with age, dietary calcium, and 3`-end region polymorphisms[J]. J Bone Miner Res, 1998,13(6):925-930.
  • 5Lorentzon M, Lorentzon R, and Nordstrom P. Vitamin D receptor gene polymorphism is associated with birth height, growth to adolescence, and adult stature in healthy Caucasian men: A cross-sectional and longitudinal study[J]. J Clin Endorcrinol Metab, 2000
  • 6Morrison NA , Chengqi J, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles[J]. Nature, 1994,367:284-287.
  • 7Riggs BL, Nguyen TV, Melton LJ, et al. Contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women[J]. J Bone Miner Res, 1995,10(6):991-996.
  • 8Viitanen A, Laitinen K, Laitinen K, et al. Common polymorphism of the Vitamin D receptor gene is associated with variation of peak bone mass in young finns[J]. Calcif Tissue Int, 1996,59(4):231-234.
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  • 10Taylor JA, Hirvonen A, Watson M, et al. Association of prostate cancer with vitamin D receptor gene polymorphism[J]. Cancer Res, 1996, 56:4108-4110.

二级参考文献16

  • 1[1]Kroger H, Mahonen A. Vitamin D receptor genotypes and bone mineral density[J]. Lancet,1995,345:13
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  • 3[3]Hustmyer FG, Peaeock M, Hui S, et al. Bone mineral density in relation to polymorphism at the vitamin receptor gene locus [J]. J Clin Invest, 1994,94:2130
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  • 5[5]Yamagata Z, Miyamura T, Lijima S, et al. Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women[J]. Lancet, 1994,344:1007
  • 6Tsai KS,Hsu SHJ,Cheng WC,et al.Bone mineral density and bone markers in relation to vitamin D receptor gene polymorphisms in Chinese men and women.Bone,1996,19:513-518.
  • 7Dawson-Hughes B,Harris SS,Finneran S.Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype.J Clin Endocrinol Metab,1995,80:3657-3661.
  • 8Ensurd KE,Stone K,Cauley JA,et al.Vitamin D receptor gene polymorphisms and the risk of fracture in older women.For the study of osteoporotic fractures research group.J Bone Miner Res,1999,14:1637-1645
  • 9Morrison NA,Yeoman R,Kelly PJ,et al.Contribution of transacting factor alleles to normal physiological variability:vitamin D receptor gene polymorphism and circulating osteocalcin.Proc Natl Acad Sci USA,1992,89:6665-6669.
  • 10Bass F,Bikker H,Van Ommen GJB,et al.Unusual scarcity of restriction site polymorphism in the human thyroglobulin gene.A linkage study suggesting autosomal dominance of a defective thyroglobulin allele.Hum Genet,1984,67:301-305.

共引文献43

同被引文献88

引证文献8

二级引证文献44

大连医科大学学报
2004年 第3期

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