两种中药制剂治疗原发性骨质疏松症的研究

Clinical Study on the Treatment of Primary Osteoporosis with Two Traditional Chinese Drugs

目的 :比较两种中药制剂对骨质疏松症的疗效。方法 :将 4 6例患者随机分为Ⅰ、Ⅱ两组 ,Ⅰ组服用健骨颗粒剂 ,Ⅱ组服用骨松宝颗粒剂 ,观察 6个月 ,治疗前后使用UBIS 5 0 0 0型超声骨密度仪检测骨密度。结果 :两组患者治疗后的超声振幅衰减值和骨硬度均明显升高 (P <0 .0 1) ,而相对骨折危险性明显减小 (P <0 .0 5 )。结论 :两种中药制剂均能提高骨密度、减少骨折危险性 ,从而有效地治疗原发性骨质疏松症。

Objective: To compare the therapeutic effects of two traditional Chinese drugs in treating primary osteoporosis (POP).Method:Forty-six cases of POP were randomly divided into two groups: group Ⅰ (n=24)and group Ⅱ(n=22).Patients with POP were treated by Jian′gu granule in group Ⅰ and Gusongbao grenule in group Ⅱ respectively.The treatment course was 6 months. Bone density were measured by quantitative ultrasound UBIS 5000 before and after the treatment. Result:Both broadband ultrasound attenuation and bone stiffness in two groups increased significantly(P<0.01),while relative risk of fracture decreased significantly(P<0.05). Conclusion: The therapeutic effects of Jian′gu granule and Gusongbao granule in treating POP are related with increasing bone density and decreasing relative risk of fracture.