流行性出血热病人尸体肾脏中IgE型免疫复合物沉积的观察

The Observation of IgE immune Complex Deposition in Cadaveric Kidney of the Patient with Epidemic Kaemorrhagic Fever (EHF)

本文应用免疫酶组化法检测EHF尸体肾脏IgE型免疫复合物,并检测同一肾检病人血清中IgE及其复合物。结果发现,EHF病人肾组织中有IgE型免疫复合物的沉积,通过抑制试验证明复合物为IgE型。病人血清中亦检出较高水平的IgE型复合物。这说明IgE型复合物可随血流沉积于肾脏参与EHF中晚期发病过程。

The IgE immune complex deposited in the cadaveric kidney of EHF patients was detected with immufloenzymatic and histochemical test. The IgE and IgE complexes in the se-rum of the same cases were also determined. The results showed that there was IgE immune complex deposited in the kidney of EHF patients and it was confirmed by the inhibi tion test. In the serum of the patients IgE and IgE complex levels were markedly higer than that in the control group. These results indicate that IgE complex in the blood may deposit in the kidney and participate in the pathogenesis of EHF