摘要
目的 :研究成人特发性血小板减少性紫癜 (ITP)血小板膜糖蛋白阳性率与疗效的关系。方法 :利用流式细胞仪、单克隆抗体测定 73例成人特发性血小板性紫癜 (IdiopathicThrombocytopenicPurpura ,ITP)和 19例正常对照血小板膜糖蛋白GPⅡa、GPⅨ、GPⅢa、GPIb、GPⅡb阳性率。观察血小板膜糖蛋白阳性率与成人ITP疗效的关系。结果 :19例正常对照组阳性率均 >97% ;4 0例GP阳性率 <85 %ITP患者组疗效明显低于阳性率≥ 85 %ITP患者组 (F =18 2 5 ,P <0 0 0 5 ) ;5 1例女性ITP患者组疗效明显低于 2 2例男性ITP患者组 (F =8 4 2 4 ,P <0 0 5 ) ;成人ITP患者疗效与血小板膜糖蛋白阳性率呈明显正相关 (R =1 0 ) ,73例成人ITP血小板膜糖蛋白阳性率愈低治疗疗效愈差。成人ITP血小板膜糖蛋白阳性率在一定程度上反应患者病情的程度 ,为成人ITP初诊患者选择治疗方案提供可行性实验依据。
Objects: To investigate the correlationship between the platelet membrane glycoproteins(GP) positive rate and the treatment response rate in adult idiopathic thrombocytopenic purprua (ITP). Methods: Five types of platelet membrane of glycoproteins (GPⅡa,GPⅨ,GPⅢa,GPⅠb,GPⅡb) in 73 ITP patients and 19 normal controls were detected by flow cytometer through the corresponding monoantibodies. Results: The GP positive rates were all above 97% in the 19 normal controls. The GP positive rates were lower be low 85% in 40 cases of the 73 ITP patients,and higher over 85% in the other 33 cases. There was significant statistic difference between the two groups (F value 18 25,P <0 005). Response rates of 51 female patients were significantly lower than 22 males (F value 8 424,P <0 05). The GP positive rate were positively correlated with clinical response rates in adult ITP( r =1 0). Conclusion: The platelet membrane GP positive rates of adult ITP could imply the disease status in a way and provide experimental evidence for the choice of therapeutic regimens.
出处
《江苏大学学报(医学版)》
CAS
2004年第30期229-231,共3页
Journal of Jiangsu University:Medicine Edition
基金
常州市科学技术基金项目 (常科 99第 63号 )
关键词
ITP
血小板膜糖蛋白
疗效
Idiopathic Thrombocytopenic Purpura,Adult
Platelet glycoprotein
Response rate