人精浆免疫抑制物质的测定及应用

Detection and Clinical APPicaticn of ImmimosuPPressive Substance in Human Seminal Plasma

以补体结合抑制试验分别检测生育、不育、妻子流产及婚检男性的精浆免疫抑制物质(HSPIM),120例生育男性HSPIM含量大于360U/ml的为104例,占86.7％;80例婚检男性HSPIM低于360U/ml的为11例,占13.8％;553例不育、135例妻子流产及16例无精症男性HSPIM低于360U/ml的分别为319例占57.6％、84例占62.2％、3例占18.7％。生育组及婚检组与不育组流产组HSPIM含量比较差异均非常显著(P<0.01);输精管结扎男性和无精症患者HSPIM含量与婚检男性比较无显著性差异(P>0.05)。结果提示HSPIM是一种妊娠相关蛋白,HSPIM缺乏往往引起不育和妻子流产。

Immunosurppessive substamce in human seminal plasma (HSPIM) has been determined by anticomplement test in proven fertile males and various groups of male patients. HSPIM 86,7% of the proven fertile males (104/120) way more than 360U/ml. Incidences with of less 360U/ml in 553 infertile males, 135 men whose spouse had habitual abortion, 16 cases men with azoospermia and 80 men undergoing physical check-up before marriage were 57.6%, 62.2%, 18.7% and 13.8%respecsively. Differences of HSPIM concentration amoung ferfile, infertile men and those whose spouse had habitual abortion was of great significance (p<0.01) , but the differences among vasectomized men, men with azoospermid and those undergoing marital physica examination had ho significance.