测定白细胞介素2以监视肾移植排异的初步研究

Assessment of IL-2 Production by PBL in Allograft Renal Recipients during Acute Rejection Episodes

本文测定了28例肾移植患者术前术后PBL和白细胞介素2(IL-2)的产生,并与正常人作了比较。在85人次测定中有7次排异反应。术前PBL与正常值无明显差异,IL-2产生略有降低;术后稳定期PBL和IL-2产生都明显下降;排异期急速上升,甚至高于正常水平。一些典型病例的动态观测也表明,术后无排异时IL-2产生逐渐恢复;排异时急速增加。本文引入IL-2×PBL的概念,即每毫升血液的PBL产生IL-2的能力代替IL-2,由于同时考虑了PBL的改变,所以监测排异反应的阳性率和准确率均优于IL-2指标。

The number of PBL and interleukin 2 production of 28 cases of allograft renal recipient were detected at different st ages and com pared with that of health volunteers. Among 85 assays 7 acute rejections were included.The average count of PBL of patients was undifferentiated from nolmal level before operation, IL-2 production slightly decreased. During stable stage both of them significantly decreased.At acute rejection IL-2 production increased beyond normal level.Dynamic results in some patients also showed that high synthesis of IL-2 generally correlated with rejection, however,there were some exceptions. In order to reflect the ability in vivo secreted IL-2,IL-2xPBL was used instead of IL-2, Primary result suggested that the former was much better.