纳洛酮对人体短时剧烈运动中机体免疫功能的影响

Effect of Naloxone on Human Immune Function after a Short Period of Violent Training

本文就纳洛酮对击剑运动员短时间剧烈运动前后机体免疫功能的影响进行了初步探讨,结果表明:运动前静脉注射纳洛酮后跑步4000米,外周血T细胞亚群的变化表现为CD_8^+细胞亚群百分率升高,CD_4^+/CD_8^+比值下降;运动后外周血白细胞诱生干扰素的能力显著高于运动前,P值<0.01。运动后NK细胞活性及白细胞吞噬百分率有下降的趋势,但吞噬指数显著增高。纳洛酮对外周血白细胞诱生干扰素的能力、NK细胞活性及白细胞吞噬功能均未见有明显影响。

In this primary study we investigated the effect of naloxone on immune function of fencing sportsmen in comparison with before and after a short period of violent training. The results showed: 1. After the sportsmen injected naloxone by i. v. run 4,000 metres dash,the percentage of CD8+ cells from the sportsmen elevated and the ratio of CD4+/ CD8+ decreased. 2. Following the sports, the ability to induce alpha-interferon of peripheral blood leucocyte was significanly higher than that of periority (P<0.01). 3. After training,the activity of NK cells and phagocytic percentage of leucocyte from peripheral blood trended to decline, but the phagocytic index obviously elevated. In our experiments, the effect of naloxone on the induction of interfern by leucocyte from peripheral blood, activity of NK cells and phagocytic ability of leucoyte was not dominantly influenced.