摘要
有限元法(FEM)由Matlab程序实现。生物热传输模型为经典的Pennes方程,加入了血液灌流项,研究了Nd:YAG激光(1064nm)平行光束照射下肝脏组织的温度响应,在轴对称柱坐标下三维温度分布简化为径向、轴向随时间的分布,三维分布彩图还可结合时间作动画显示。数值模拟结果表明,血液灌流在光动力学疗法(PDT)中可避免局部高温,并使温度在很短的时间上升到稳态,如果该稳态温度设为治疗的最佳温度,则可增加疗效并且缩短治疗时间;组织光热参数会影响模拟结果,计算精度和时间也需折衷考虑。
The finite element method(FEM) was realized by Matlab program.Bio-heat transfer model is classical Pennes equation with blood perfusion term,the liver tissue temperature response at flat laser beam from Nd:YAG laser was researched.Under the cylinder coordinate three dimension temperature distribution was reduced to axial and radial two dimension.The three dimensions color figure animation display was possible.The results showed the blood perfusion can avoid local high temperature and make the temperature rise to a stable state in a short time.Under this stable temperature,the cure effect can be enhanced and the cure time can be shortened.The photo and thermal parameters of tissue can affect the model results,the computation precision and time should be considered compromisingly.
出处
《光电子．激光》
EI
CAS
CSCD
北大核心
2004年第7期881-884,共4页
Journal of Optoelectronics·Laser
基金
天津市自然科学基金资助项目(023602611)
关键词
有限元法
光动力学疗法
生物传热
光热效应
biology heat transfer
finite element method(FEM)
photodynamic therapy(PDT)
numerical analysis
temperature distribution
