门诊森田疗法合用氯丙咪嗪治疗强迫症的对照研究

Comparative Study of Morita Therapy and Clomipramine in Treatment of Obsessive-compulsive Disorder.

目的 探讨门诊森田疗法合用氯丙咪嗪治疗强迫症的疗效。方法 将符合条件的 62例强迫症患者随机分为研究组3 1例 (门诊森田疗法合用氯丙咪嗪组 )和对照组 3 1例 (氯丙咪嗪组 )进行对照治疗。观察两组治疗后 2、4、6、8周的疗效及治疗结束时的副作用。同时于治疗前和半年后测查两组患者生活质量评定问卷 ( GQOL-74) ,并进行比较。结果 在第 4周末时 ,两组疗效近似 ( P>0 .0 5 ) ,在第 6周和疗程结束时 ,研究组和对照组在临床疗效方面差异有显著意义 ( P<0 .0 1 )。在副作用方面两组差异无显著意义 ( P>0 .0 5 )。半年后随访 ,研究组患者生活质量得分明显高于对照组 ( P<0 .0 1 )。

Objective To investigate the clinical efficacy of Morita therapy and Clomipramine in treatment of Obsessive-compulsive disorder (OCD).Methods 62 patients who met the Chinese Classification and Diagnostic Criteria for Mental Disorders,the Third Edition (CCMD-3) for OCD were involved in this study.Morita therapy and Clomipramine efficacy in treatment of OCD were assessed with Y-BOCS and TESS compared with clomipramine.Grading questionnaires of life quality (GQOL-74) were answered before treatments and after six-month.The results at the same period were compared between the two groups.Results After four weeks the therapeutic efficacy in clinical Morita therapy and clomipramine group was similar to that in clomipramine(P>0.05).In six weeks and the last of treatment,the effects of Morita therapy and Comipramine group was significantly different with another(P<0.01).While there were no significant difference in the side effects between the two groups was after the treatment (P>0.05).The life quality was improved greatly after six month (P<0.01).Conclusion The results indicate that the Morita therapy and Clomipramine is satisfyingly effective in the treatment of OCD.