摘要
目的 研究染色体在白血病异基因造血干细胞移植方面的价值。方法 应用常规细胞遗传学方法定期检测白血病患者异基因造血干细胞移植前后常染色体、性染色体情况。结果 5例移植成功患者其中异性别 4例 ,性染色体表现为供者性染色体 ,原有异常消失 ;1例术后复发患者原有异常重现。结论 常规细胞遗传学可以作为异基因造血干细胞移植成功与否的标志和评价疗效的指标。
Objective To investigate the value of chromosome in monitoring the response to therapy in leukemia patients treated by allo-HSCT. Methods Study the normal and sex chromosome by classic cytogenetic analysis in leukemia patients before and after treatment by allo-HSCT. Results 4 patients had karyotype which showed donor′s sex chromosome in 5 successful cases and primary abnormity disappeared. One relapsed case showed abnormal chromosome again. Conclusion Classic cytogenetic analysis can be the symbol of allo-HSCT succeed or not and guide line of the curative effect.
出处
《医药论坛杂志》
2004年第10期17-18,共2页
Journal of Medical Forum
