急性病毒性脑炎血D-二聚体水平变化意义

Clinical Significance of D-dimer Levels in Children with Acute Virus Encephalitis

目的 观察D -二聚体在血中含量变化 ,了解急性病毒性脑炎发病过程中凝血功能变化及临床意义。方法 选择 2 8例急性病毒性脑炎患儿为研究对象 ,分别于急性期和恢复期采清晨空腹静脉血 ,用ELISA测D -二聚体含量 ,并与 2 8例健康儿童对照。结果 急性病毒性脑炎D -二聚体含量急性期为 (0 4 16± 0 15 6 )mg/L ,恢复期为 (0 2 0 8± 0 10 2 )mg/L ,二者比较 P <0 .0 1,差别有显著性 ;对照组为 (0 182± 0 0 92 )mg/L ,与急性期比较P <0 .0 1,差异有极显著性 ;恢复期与对照组比较P >0 .0 5 ,差异无显著性。结论 病毒性脑炎急性期存在高凝状态 ,D -二聚体水平对高凝状态的检测及治疗有重要意义。

Objective To explore the content changes of D-dimer in blood,investigate the clinical significance of blood coagulant function in the process of acute virus encephalitis.Methods 28 children with acute virus encephalitis were selected,venous blood specimens were taken with empty stomach in the morning.The contents of D-dimer was determined with ELISA,28 health children as control.Results The level of D-dimer in patients during acute period was 0.146±0.156mg/L,in recovery was 0.208±0.102mg/L(vs acute stage, P< 0.01 ).The level of D-dimer in control was 0.182±0.092mg/L(VS acute stage,P< 0.01 ).In recovery and control,two groups were about the same ,P>0.05.Conclusion Hypercoaguliability was in the acute period of virus encephalitis.D-dimer might play a role in detection or therapy with the hypercoaguliability condition.