高血压病Ⅲ型前胶原与一氧化氮血管紧张素Ⅱ相关性的研究

Study of Relationship between NO,Ang Ⅱand PC Ⅲ in Patients with Hypertension

目的 研究高血压病 (EH)患者Ⅲ型前胶原 (PCⅢ )与一氧化氮 (NO)、血管紧张素Ⅱ (AngⅡ )之间的相关性。方法 测定 4 3例高血压患者及 2 0例正常人循环中Ⅲ型前胶原、一氧化氮及血管紧张素Ⅱ浓度并进行相关分析。结果 高血压病患者循环中Ⅲ型前胶原、血管紧张素Ⅱ浓度显著高于正常对照组 (P <0 .0 1) ,一氧化氮浓度显著低于正常对照组 (P <0 .0 1)。结论 高血压病患者循环中Ⅲ型前胶原与血管紧张素Ⅱ增高 ,二者呈正相关 ,一氧化氮浓度降低 ,且与Ⅲ型前胶原呈负相关。

Objective To study the relationship between NO.Ang Ⅱ and PC Ⅲ in patients with hypertension. To exam the PC Ⅲ NO、and Ang Ⅱ density of 43 cases with hypertension and 20 normal people.Results The density of PC Ⅲ and Ang Ⅱ in patients with luypertension is obviously higher than that of control group,the density of NO is obviously lower than that of control group,The PC Ⅲ is in positive relation with Ang Ⅱ,and in ngeative relation with NO.Conclusion The PC Ⅲ and Ang Ⅱ increased in patients with hypertension and there is a positive relation between them,the density of NO decreased and in negative relation with PC Ⅲ.