摘要
目的探讨新兵联合接种甲肝疫苗和乙肝疫苗的免疫效果及安全性。方法200名健康新兵随机均分为4组。A组:于0、6个月接种2剂甲肝减毒活疫苗,B组:于0、1、6个月接种3剂乙肝疫苗,C组:一侧上臂于0、6个月接种2剂甲肝减毒活疫苗,另一侧上臂于0、1、6个月接种3剂乙肝疫苗,D组:于0、6个月接种2剂甲、乙型肝炎联合疫苗。于首针后7个月时测定甲肝和乙肝抗体滴度,观察免疫效果和安全性。结果甲肝和乙肝疫苗双上臂同时接种,抗-HAV和抗-HBs的阳转率分别是100%和91.84%,与各自单独接种的免疫效果无显著性差异;按0、6个月2剂免疫程序接种甲、乙型肝炎联合疫苗,抗-HAV和抗-HBs的阳转率分别是100%和92.5%,与各自单独接种的免疫效果亦无显著性差异。结论新兵同时接种甲肝和乙肝疫苗安全、有效,若经济条件允许则可接种甲、乙型肝炎联合疫苗。
Objective To study the immunogenicity and safety of concurrent hepatitis A and hepatitis B vaccination in recruits.Methods Two-hundred recruits were randomly divided into A,B,C,D four groups:group A received hepatitis A vaccines,group B received hepatitis B vaccines,group C received hepatitis A vaccines in the right arms and received hepatitis B in the left arms,group D received combined hepatitis A and B vaccine.The immunogenicity and safety were assessed later7months after the first dose.Result In group C,the seropositive rate for antibody to hepatitis A and B were100%and91.84%respectively.In group D,the seropositive rate for antibody to hepatitis A and B were100%and92.50%respectively.There was no significant difference between being vaccinated through the combined way and through the solely way.Conclusion It is effective and safe for recruits to receive concurrent hepatitis A and B vaccines.
出处
《实用医药杂志》
2004年第7期645-647,共3页
Practical Journal of Medicine & Pharmacy
关键词
甲、乙型肝炎联合免疫
免疫效果
安全性
Concurrent hepatitis A and hepatitis B vaccination Immunogenicity Safety