腹腔灌洗联合前列地尔治疗重症急性胰腺炎疗效观察

Peritoneal Lavage Combined with Alprostadil for the Treatment of Severe Acute Pancreatitis

目的 :了解腹腔灌洗联合前列地尔对重症急性胰腺炎的疗效。方法 :回顾分析内科保守治疗组 (A组18例 )、腹腔灌洗组 (B组 12例 )、腹腔灌洗前列地尔联合治疗组 (C组 15例 )三组间腹痛缓解时间、消失时间 ,血淀粉酶恢复正常时间 ,C 反应蛋白 (CRP)浓度变化 ,急性肺损伤 (ALI)的发生率 ,死亡率的差异。结果 :C组血淀粉酶恢复正常时间短于A组和B组 ;C组CRP浓度、ALI的发生率均低于A组和B组。腹痛缓解时间、消失时间B组和C组均短于A组 (P <0 .0 5 ,但B、C两组间比较差异无统计学意义。腹腔灌洗和前列地尔有降低死亡率的趋势 ,但 3组间死亡率差异无统计学意义 (P >0 .0 5 )。结论

Objective: To evaluate the effect of peritoneal lavage combined with alprostadil for the treatment of severe acute pancreatitis(SAP).Method: Time of abdominal pain released, abdominal pain disappeared, recovery time of blood amylase, rate of acute lung injury(ALI), C-reactive protein(CRP) concentration and mortality rate were all compared amang the three groups(conservative treatment 18cases, group A; peritoneal lavage 12cases, group B; peritoneal lavage combined with alprostadil 15 cases, group C).Result: Recovery time of blood amylase, rate of ALI, CRP concentration were all more decreased in group C than in group A and B. Time of abdominal pain released and abdominal pain disappeared was more shortened with peritoneal lavage, but there was no statistical difference for time of abdominal pain released and abdominal pain disappeared between B and C groups. Mortality rate was the same among the three groups(P>)0.05)).Conclusion: Peritoneal lavage combined with alprostadil has more effects on the recovery of SAP than conservative treatment and peritoneal lavage respectively.