缬沙坦或吲达帕胺对中青年男性高血压患者性功能影响

Effects of with Valsartan or Indapamide on Sexual Activity in Middle-aged Hypertensive Men

目的 探讨缬沙坦和吲达帕胺对中青年男性高血压患者降压的疗效以及对性功能的影响。方法 将入选的 12 0例患者随机分为两组 ,一组服用缬沙坦 ,另一组服用吲达帕胺 ,观察治疗 8周前后血压及性功能变化。结果 缬沙坦和吲达帕胺均能显著降压 (P <0 0 1)。缬沙坦治疗后明显增加了勃起功能指数 (17.7± 4 6vs 14± 5 6 ,P <0 0 1)和每周性交次数 (3 2± 1 2次 /周vs 2 2±1 1次 /周 ) ,两者差异显著 (P <0 0 1) ;而吲达帕胺治疗前后患者性功能无明显改变 (P >0 0 5 )。结论 缬沙坦在降压的同时能显著改善男性性功能。

Objective To evaluate the effects of Valsartan or Indapamide on sexual activity in middle-aged hypertensive men. Methods One hundred and twenty hypertensive men aged 35 to 55 years, all married and without any previous sexual dysfunction were randomly assigned to receive valsartan(80 mg/d) or indapamide(1.5 mg/d) for 8 weeks. Sexual activity was evaluated by using the international index erectile function-5 (IIEF-5) and the number of sexual intercourse episodes per week. Results The antihypertensive effects was similar in two groups. Valsartan significantly increased the score of sexual activity (from 14.1±5.4 to 17.7±4.6, P<0.01) and the episodes of sexual intercourse (from 2.2±1.1 to 3.6±1.2, P<0.01). In the Indapamide groups, antihypetensive treatment had no impact on the sexual activity in patients (score from 13.7±6.1 to 12.9±5.9; the episodes from 2.4±1.3 to 2.1±0.9, P>0.05). No one complained of sexual dysfunction in the Valsartan group, however, 6 men (10) treated with Indapamide complained about sexual dysfunction symptoms. Conclusion Beside antihypertensive effect, valsartan may obviously improve the sexual activity in hypertensive men. Indapamide appears had no influence on sexual function.