醛固酮合成酶基因多态性(C/T)与高血压患者左室肥厚相关性研究

Aldosterone Synthase Gene Polymorphisms and Left Ventricular Hypertrophy in Hypertensive Patients

目的 研究原发性高血压患者醛固酮合成酶CYP11B2 (- 344C/T)多态性与左室肥厚的关系。方法 应用多聚酶链式反应 (PCR)、限制性内切酶方法检测 4 2 0例原发性高血压患者CYP11B2 (- 344C/T)基因型。用M型超声心动图测量舒张末期左心室内径 (LVDd) ,左心室后壁厚度 (LVPWT) ,舒张末期室间隔厚度 (INSTd)。结果 三组基因型间醛固酮 (ALD)浓度差异无显著性 ;左室肥厚 (LVH)与非左室肥厚 (NLVH)组基因型、等位基因频率分布差异无显著性 (P >0 0 5 )。LVH组血浆ALD浓度显著高于NLVH组 (15 6 .95± 4 7.5 5vs 14 6 .33± 4 5 2 9,P <0 0 5 ) ;按ALD水平四分位数分成四级 ,OR值随醛固酮水平的增加而递增 ,呈现明显的剂量反应关系。结论 醛固酮合成酶CYP11B2 (- 344C/T)多态性与左室肥厚无关 ;ALD水平是高血压患者左室肥厚的危险因素。

Objective To study the relationship of gene polymorphism of aldosterone synthase CYP11B2(-344C/T)and left ventricular hypertrophy in hypertensive patients. Methods The genotype of CYP11B2 was monitored by polymerase chain reaction (PCR-RFLP) in 420 hypertensive. LVDd, LVPWT and INSTd of left ventricular were detected by echocardio graphy. Results The genotype frequence rate of TT,CT,CC and allele frequency distribution had no significant difference in left ventricular hypertrophy and non-left ventricular hypertrophy(P>0.05); the plasma aldosterone levels in LVH group were higher than in NLVH group(156.95±47.55 vs 146.33±45.29,P<0.05); the odds ratio for left ventricular hypertrophy was higher corresponding with the aldosterone levels. Conclusion No assoeiation between aldosterone synthase gene polymorphisms and LVH was found. The plasma levels of aldosterone may be related to LVH in hypertensive patients.