慢性阻塞性肺疾病患者外周血各免疫指标的相互关系探讨

Correlation discuss of each immunity index in around blood in patients with chronic obstructive pulmonary diseases

目的 探讨慢性阻塞性肺疾病 (COPD)患者外周血可溶性白细胞介素 -Ⅱ受体(SIL - 2R)、白细胞介素 - 8(IL - 8)、免疫球蛋白、T淋巴细胞亚群相互关系。方法 选择发作期COPD患者 2 6例 ,缓解期COPD患者 30例 ,健康对照者 30例 ,用ELISA法测定各组患者血清SIL - 2R和IL - 8,免疫散射速率法测定IgG和IgA ,单克隆抗体免疫组化荧光染色法测定T淋巴细胞CD3 + ,CD4+ ,CD8+ ,并进行分析。结果 急性发作期和缓解期COPD患者SIL - 2R ,IL - 8,CD8+ 增高 ,IgG ,IgA ,CD3 + ,CD4+ 及CD4+ /CD8+ 比值降低 ,与对照组比较有显著性差异 (P均 <0 .0 1)。结论 慢性阻塞性肺疾病患者存在免疫功能低下 ,在治疗过程中 ,适当给予增强免疫治疗 。

Objective It is to discuss the correlation of dissolubility interleukin-2 (SIL-2R) receptor, interleukin-8 (IL-8), immunoglobulin, T-lymphocyte subgroup in around blood in the patients with chronic obstructive pulmonary diseases (COPD).Methods 26 patients with COPD in acute stage, 30 patients with COPD in catabatic stage and 30 healthy persons for antitheses were chosen. The SIL-2R and IL-8 in each group was measured with ELISA method, the IgG and IgA were determined with rate nephelometry method and the CD 3 +, CD 4 + and CD 8 + were determined with immunofluorescence techniques. Then the results were analyzed.Results The contents of SIL-2R, IL-8 and CD 8 + were increased, and the contents of IgG, IgA, CD 3 +, CD 4 + and CD 4 +/CD 8 + were decreased. The difference was significant compared with control group (P<0.01).Conclusion Patients with COPD have a bad immune function. It is helpful to use immune treatment for patients with COPD to decrease the chance of repeating respiratory tract infect.