非发酵菌致危重患者获得性肺部感染118例分析

Analysis of 118 cases of hospital acquired lung infection caused by non-fermentive bacteria

目的 探讨我院ICU内危重患者非发酵菌致肺部感染的临床特征和对常用抗生素的敏感性。方法 对 118例ICU内危重患者非发酵菌所致的肺部感染的临床资料和细菌学药敏试验做回顾性分析。结果 118例患者细菌培养提示主要非发酵菌为铜绿假单胞菌 70株 ,鲍曼氏不动杆菌 5 6株 ,脑膜脓毒金黄杆菌 5 2株 ,嗜麦芽假单胞菌 4 6株 ,88%为混合感染 ,细菌耐药性高 ,头孢哌酮 /舒巴坦、哌拉西林 /他唑巴坦为相对敏感抗生素。结论 非发酵菌致肺部感染多发生于有各种基础病、免疫低下、长期使用抗生素的老龄患者 ,细菌耐药性高 。

Objective To study the clinical characteristics of the hospital acquired lung infection caused by non-fermentive bacteria for serious-ill patients of intensive care unit in our hospital and their antimicrobial susceptibility. Methods The clinical data of 118 cases of lung infection caused by non-fermentive bacteria and drug susceptibility were analyzed. Results The most common pathogens were pseudomonas aeruginesa (70 strains), acinetobacter baumanni (56 strains), chryseo bacteria (52 strains), stenotrophomenas maltophilia (46 strains). 88% of the cases were mixed infections. Isolates were highly resistant to most of antimicrobial agents. Cefoperazone/sulbactan, piperacillin/tazobactan were the more sensitive antibiotics. Conclusions The lung infection caused by non-fermentive bacteria existed most commonly in old patients who suffered from various underlying disease, longtime antibiotic overuse and immunodeficiency. Because the clinical isolates were highly resistant to most kinds of antimicrobial agents, the antibiotics should be selected according to the results of bacterial susceptibility test.