膦甲酸钠治疗慢性乙型重型肝炎临床疗效观察

Clinical effect of foscarnet in treating patients with chronic fulminant hepatitis B.

目的 探讨膦甲酸钠 (PFA)治疗慢性重型肝炎 (CSH)的临床效果。方法 选择CSH患者 42例 ,随机分为治疗组 ( 2 1例 )及对照组 ( 2 1例 ) ,两组均给予综合基础保肝、支持疗法及防治有关并发症等治疗 ,治疗组另加用PFA注射液 2 .4g静脉滴注 ,每日 2次 ,应用 4周～ 8周。结果 治疗组无论从症状及肝功能恢复、HbeAg阴转、HBVDNA水平下降程度及治愈率等方面均明显优于对照组 (P <0 .0 1)。结论 PFA对于重型肝炎治疗 ,具有改善症状 ,抑制HBV复制 ,促进肝功能恢复 。

Objective To observe the clinical effect of foscarnet in treating patients with chronic fulminant hepatitis B.Methods 42 patients were randomly divided into 2 groups.Two groups were both treated by basic surporting therapy and preventing the related complications.At the same time,the treatment group were treated by PFA(2.4g iv,bid for 4 weeks).In the end,the liver function and other indexes were observed.Results The clinical effect of the treatment group was superior to the control group( P<0.01 ).Conclusions Foscarnet can be used to treat patients with chronic fulminant hepatitis B.