复方配伍减轻关木通肾毒性的实验研究

Nephrotoxicity of Caulis Aristolochiane Manshuriensis(关木通) reduced by compouned formula cooperation

目的 :比较单味关木通及其复方龙胆泻肝丸、导赤散对大鼠产生的肾毒性反应及严重程度。方法 :大鼠分别给予含关木通 4g/kg·d的关木通水煎液、龙胆泻肝丸水液、导赤散水煎液灌胃 12周 ,测定相关肾功能指标并对肾组织进行形态学检查。 结果 :龙胆泻肝丸与导赤散对大鼠造成的肾脏损害较单味关木通为轻。结论 :复方配伍能够减轻关木通肾毒性。

Objective: To observe the changes of nephrotoxicity on rats caused by LDXG (龙胆泻肝丸),TZS (导赤散) and Caulis Aristolochiane Manshuriensis decoction. Methods: 30 SD rats were randomly divided into 4 groups: Groups A,B,C were fed with decotion which contain Caulis Aristolochiane Manshuriens at the dose of 4g/kg·d,control group was D(n= 6). were fed with equal water. Blood was taken from caudal vein and 24h urine got at the end of week 12 to examine renal function,the kidneys were harvested on the last day for morphological examination. Results: Caulis Aristolochiane Manshuriensis decoction caused serious renal damage compared with LDXG decoction and TZS decoction. Conclusion: Nephrotoxicity of Caulis Aristolochiane Manshuriensis could be reduced by compouned formula cooperation.