C反应蛋白、白细胞介素6及肿瘤坏死因子α与2型糖尿病血脂异常的相关性研究

A Relative Study between C-reactive Protein,Interleukin-6,Tumor Necrosis Factor-α and Hyperlipemia in Type 2 Diabetes

目的 研究C反应蛋白 (CRP)、白细胞介素 6 (IL - 6 )及肿瘤坏死因子α (TNFα)与 2型糖尿病血脂异常的关系。方法 测定 4 7例非糖尿病对照者及 31例 2型糖尿病患者的总胆固醇 (TC)及甘油三酯 (TG)等血脂指标 ,同时检测CRP、IL - 6及TNFα水平。比较两组间的差异 ,将上述指标与血脂作相关性分析。结果 2型糖尿病组与对照组IL - 6分别为 (172 5± 2 8 33) pg/ml,(97 9± 5 7 1)pg/ml (P <0 0 5 ) ;CRP及TNFα在两组间差别无显著性意义 (P >0 0 5 )。 2型糖尿病患者的CRP、IL - 6、TNFα与TG呈正相关 (r值分别为 0 5 2、 0 90、 0 6 8,P <0 0 1)。IL - 6与 2型糖尿病患者TC呈正相关 (r值为 0 6 3,P <0 0 1)。结论 CRP、IL - 6及TNFα与 2型糖尿病高甘油三酯血症的发生有关 ;IL - 6与 2型糖尿病患者高胆固醇血症的发生亦有关。

Objective To study the relationship between C-reactive protein,interleukin-6,tumor necrosis factor-α and hyperlipemia in type 2 diabetes.Methods 47 control subjects and 31 type 2 diabetes patients were observed.They were control group and type 2 diabetes group.We determined their indexes of lipoprotein metabolism,such as plasma total cholesterol and triglyceride level,et al.At the same time we determined the CRP,IL-6 and TNFαlevel.We compared the difference between the two groups.Pearson relation analysis was done between these indexes and lipoprotein level.Results The level of IL-6 in type 2 diabetes group was significantly higher than that in the control group (172.5±28.33pg/mlvs 97.9±57.1pg/ml,P<0.05).There were no statistic significant differences in the CRP and TNFα level of the two groups(P>0.05).In type 2 diabetes group,through Pearson analysis,CRP,IL-6 and TNFα had positive relation with the diabetes patients′ TG level (r=0.52,P<0.01; r=0.90,P<0.01;r=0.68,P<0.01).IL-6 had positive relation with the diabetes patients′ TC level (r=0.63,P<0.01).Conclusion CRP,IL-6 and TNFα was related with the type 2 diabetes patients′ high TG level.IL-6 was related with the type 2 diabetes patients′ high TC level.