联合检测组织多肽特异性抗原和癌胚抗原在鉴别良恶性胸液的诊断价值

Study on diagnosic value of analyzing tissue polypeptide antigen specific(TPS) and carcinoembryonic antigen(CEA) in benign and malignant pleural effusion

目的 探讨联合检测组织多肽特异性抗原 (TPS)和癌胚抗原 (CEA)在鉴别良恶性胸液的诊断价值。方法 采用酶联免疫吸附测定法 (ELISA)检测胸液及血清中TPS的含量和免疫放射分析法 (RIA)测定胸液及血清CEA的水平 ,4 8例胸液中 2 2例良性 2 6例恶性。结果 恶性组血清和胸液中TPS、CEA浓度及阳性率均高于良性组 ,有显著性差异 (P <0 0 0 1)。结论 联合检测胸液中的CEA。

Objective To explore the diagnostic value of tumor marker TPS, CEA in differentiating benign and malignant pleural effusion. Methods The CEA、TPS level of serum and pleural effusion in 22 benign cases and 26 malignant cases were detected by RIA and ELISA. Results The results showed that CEA and TPS levels of serum and pleural effusion in malignant cases were significant higher than those in benign cases( P <0 001). Conclusion Combining the CEA and TPS test might to be very useful in differentiating malignant pleural effusion from benign one.