同步间歇指令通气在新生儿呼吸衰竭中的临床疗效分析

Analysis clinical effect of SIMV in neonate infants with failure of respiration

目的探讨同步间歇指令通气(SIMV)在新生儿呼吸衰竭中的临床效果。方法应用SIMV治疗45例新生儿呼吸衰竭患儿,并观察上机后的临床表现、动脉血气的变化及并发症的发生情况。结果36例于实施SIMV 30 min后,呼吸困难、紫绀减轻或消失(80.0%),应用SIMV 6h内动脉血氧分压由(5.74±1.16)kPa升高至(8.25±2.12)kPa,动脉血二氧化碳分压由(7.35±1.78)kPa降低至(5.61±1.52)kPa,血氧饱和度由65.87±12.75升高至87.67±7.25,pH值由7.23±0.19升高至7.35±0.05。45例中完全缓解37例(82.2%),改善5例(11.1%),无效3例(6.7%),总有效率达93.3%。结论SIMV 治疗新儿呼吸衰竭临床效果显著且安全。

Objective: To analyze the clinical effect of synchronized intermittent mandatory ventilation (SIMV) in neonate with failure of respiration. Methods: SIMV was used to treated 45 neonate infants with failure of respiration and clinical data including the clinical manifestation, arterial blood-gas analysis and complications associated with failure of respiration were collected. Results: 30 minute after using SIMV, dyspnea and cyanosis of 36 patients (80.0%) alleviated or disappeared, 6 hours after SIMV, PaO2 increased from (5.74±1.16) kPa to (8.25±2.12) kPa, PaCO2 decreased from (7.35±1.78) kPa to (5.61±1.52) kPa, SaO2 lifted from 65.87±12.75 to 87.67±7.25, PH elevated from 7.23±0.19 to 7.35±0.05. The results showed that the clinical symptoms disappeared in 37 of 45 patients with failure of respiration, improved in 5 patients, 3 had no efficacy, and the total efficiency was 93.3%. Conclusion: The treatment of breath failure in newborn infants using SIMV is very effective and safe.