贵州苗族人群HLAI类基因的多态性研究

The Polymorphism of HLA Class I Genes in Guizhou Miao Population

用第11届国际组织相容性会议人类学课题的第2套血清180份,以标准方法检测了58例贵州苗族人群的HLA-A、-B、-C位点抗原并计算了其基因频率。苗族人群最常见的Ⅰ类抗原及其基因频率是:HLA-A2 0.310,A11 0.431、BW46 0.160,BW60 0.125,BW75 0.112,CW7 0.174,CW9 0.176。用本研究所获的有代表性的基因频率和同批抗血清所获的其他民族以及贵州汉族的相应频率比较,贵州苗族和贵州汉族、布依族以及南方汉族接近,和北方汉族间的差异具显著性。树系图也证实了这种聚集。本研究支持中华民族可分为南北两大人群的观点。

Guizhou is the province where about half of the total Miao people lives. According to arrangment of the 11th International Histocompatibility Workshop and Conference Anthropology Component, with standard methods and second set antisera, the HLA-A,-B,-C locus antigens of 58 non-kindred Miao adults were typed. The most frequent alleles found in Guizhou Miao population are:HLA A2 (gene frequency 0.310), A11(GF 0.431), BW46 (GF 0.160),BW60(GF 0.125), BW75 (GF 0.112), CW7 (GF 0.174), CW9(GF 0.176). Comparison of allele frequencies has shown:Guizhou Miao is close to Guizhou Han, Buyi and southern Han, but not nouthern Han. This cluster is confirmed by dendrogram of major nationalities in the world. Our data support the point of view about two major groups of Chinese people on HLA polymorphism.