荆花胃康胶丸治疗幽门螺杆菌相关性消化性溃疡的疗效和安全性

Comparison of the efficacy and safety of Jinghuaweikang capsules and famotidine in treatment of Hp related peptic ulcer

目的:比较荆花胃康胶丸与法莫替丁三联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡的疗效和安全性。方法:181例Hp阳性消化性溃疡患者分为2组,中药组131例,服用荆花胃康胶丸2粒,tid,疗程6周;三联组口服法莫替丁,20mg,bid,疗程6周,阿莫西林1.0g,bid,疗程2周,甲硝唑0.4mg,bid,疗程2周。治疗前和疗程结束后4周Warthin Starry银染色或14C-呼气试验检查Hp。结果:中药组第1周上腹痛缓解率(70.22％)高于三联组(49.00％,P<0.05)。第2周后两组上腹痛缓解率相近,均高于90％。中药组溃疡愈合率为65.65％,Hp根除率为33.59％。2组不良反应小。结论:荆花胃康胶丸缓解上腹痛见效快,溃疡愈合率高,不良反应小,可作为治疗Hp的补充方案,特别是为经三联治疗失效的病例或不适宜抗生素治疗的患者提供了较好的方法。

Objective:To compare the efficacy and safety of Jinghuaweikang capsules and famo-tidine triple therapy in treatment of Helicobacter pylori (Hp) related peptic ulcer. Methods: 181 patients with Hp related peptic ulcer were randomly divided to receive Jinghuaweikang capsules in a dose of 2 capsules 3 times, daily for 6 weeks ( n = 131) or triple oral therapy consisted of famotidine 20mg twice daily for 6 weeks + amoxicillin 1000mg twice daily for 2 weeks + metrnidazol 40mg twice daily for 2 weeks ( n = 50). The Hp status was measured 4 weeks pre- and post- medication by Starry silver stain test and 14C breath test. Results:The remission rate of superior belly ache at the first week was 70. 22 % for Jinghuaweikang capsules group and 49. 00 % for famotidine triple therapy group (P<0.05) and at the second week a remission rate of was >% for both groups. For Jinghuaweikang capsules group, the cure rate of Hp related peptic ulcer was 65. 65 % and Hp eradication rate was 33.59% . No obvious adverse reactions were observed in both groups. Conclusion:Jinghuaweikang capsule shows rapid pain remission rate,high cure rate for ulcer and low incidence of adverse events,therefore it can be used as an alternative of famotidine triple therapy especially for those do not response to the latter.