派丽奥与牙康治疗牙周炎的疗效比较

A Comparison between the Effects of Periocline and Yakang on the Treatment of Periodontitis

目的 比较派丽奥 (2 %盐酸米诺环素软膏 )与牙康 (甲硝唑棒 )治疗牙周炎的临床疗效及对牙周可疑致病菌的清除作用。方法 选取 11例慢性牙周炎患者的 2 6颗牙周炎患牙为研究对象。患牙要求 :①牙周袋探诊深度≥ 4mm ,且探诊后出血 ;②左右对称。 2 6颗患牙随机分成实验组 (派丽奥治疗组 ) 13颗 ,对照组 (牙康治疗组 ) 13颗。观察用药前及用药后 7d和 14d ,患牙的牙周临床指标菌斑指数 (PLI)、牙龈指数 (GI)、探诊深度 (PD)、探诊出血 (BOP)的变化和龈下附着菌斑中螺旋体、球菌、杆菌的百分比 ,以及非附着菌斑中牙龈卟啉单胞菌、中间普氏菌、二氧化碳噬纤维菌等牙周可疑致病菌百分比的变化。结果 实验组和对照组患牙在用药前各项牙周临床指标和微生物学指标均无显著性差异 (P >0 .0 5 )。用药后 ,两组患牙绝大部分牙周临床指标和微生物学指标均较用药前明显改善 (P <0 .0 5 ) ,但两组间无显著性差异 (P >0 .0 5 )。结论 派丽奥与牙康均是治疗牙周炎有效、安全的局部治疗药物 ,两者的疗效无显著性差异。

Objective To compare the efficacy of 2 available periodontal systems for local delivery of antibiotics.Methods 26 teeth with moderate to severe periodontitis (PD≥4 mm) from 11 patients were selected. The teeth were randomly divided into test group and control group. Periocline (2% minocycline hydrochoride ointment) was applied to the teeth in the test group, while Yakang (local metronidazole) was applied in the control group. The data including clinical indices and microbiological parameters was collected before and on the 7+{th}, 14+{th} day after the therapy.Results Before treatment, the mean of each clinical indices and microbiological parameters between the two groups was not different (P>0.05). But both groups demonstrated significant differences with control after treatment (P<0.05), while there were no significant differences between the two test groups (P>0.05).Conclusion Both Periocline and Yakang were effective and secure local delivery drug for treating periodontitis.