奎硫平与氟哌啶醇治疗脑器质性精神障碍的对照研究

Comparison study of Quetiapine and haloperidol on brain organic mental disorder

目的 评价奎硫平治疗脑器质性精神障碍的临床疗效和不良反应。方法 将 74例脑器质性精神障碍患者随机分成奎硫平组 (37例 )与氟哌啶醇组 (37例 )进行对照治疗 ,疗程 4周。采用简明精神病量表 (BPRS)及不良反应量表 (TESS)评定疗效和不良反应。结果 治疗结束时 2组BPRS评分较入组时显著减低 (P <0 .0 1) ;奎硫平组临床有效率为 75 .5 % ,氟哌啶醇组为 70 .3% ;2组疗效无显著性差异。奎硫平组的不良反应较氟哌啶醇组少 ,其中震颤、静坐不能、扭转痉挛、肌紧张的发生率显著少于氟哌啶醇组 (P均 <0 .0 1)。结论 奎硫平治疗脑器质性精神障碍疗效与氟哌啶醇相似 ,不良反应较氟哌啶醇轻而少。

Objective It is to evaluate the clinical curative effect and untoward reaction of Quetiapine on brain organic mental disorder.Methods 74 patients with brain organic mental disorder were randomly divided into Quetiapine group and haloperidol group and treated and contrasted. The period of treatment was four weeks. The curative effect and untoward reaction were evaluated with the brief psychiatric rating scale (BPRS) and treatment emergent symptom scale (TESS).Results At the end of treatment,the scores of BPRS in both groups decreased significantly compared with that before treatment(P<0.01). The clinical effective rate was 75.5% in Quetiapine group and that in haloperidol group was 70.3%, and there was no significant difference between the two groups. The untoward reaction in Quetiapine group was fewer than that in haloperidol group, especially tremor, akathisia, acute dystonia and muscle strain, and there was significant difference between the two groups (P<0.05).Conclusion Quetiapine has similar curative effect to haloperidol in the treatment of brain organic mental disorder, but has less untoward reaction. Quetiapine is more applicable to the treatment of brain organic mental disorder.