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微量元素硒调节细胞信号传导的研究进展 被引量：1

Progresses in Selenium-Modulating Cellular Signal Transduction
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摘要 概述了硒调节细胞信号传导的功能,认为其调节信号通路有:促分裂原激活蛋白激酶信号通路、蛋白激酶C信号通路、核糖体S6蛋白激酶信号通路、转录因子NF-κB和AP-1等。同时认为氧化还原修饰信号分子是硒调节信号传导的主要机制。硒通过作用于信号传导通路而调节细胞的分化、生长、增殖和凋亡,使硒具有生物多样性。 Functions of Selenium modulating cellular signal transduction have been interpreted systematically. The signal transduction pathways modulated by selenium are associated with the following signal molecules: mitogen activated protein kinase( MAPK), protein kinase C(PKC), ribosomal S6 protein kinase, nuclear factor NF-κB and AP-1. Selenium regulates the signals through their redox reactions. Selenium affects cellular differ-entiation, growth, proliferation and apoptosis by modulating signal transduction.
作者 廖海星 丁尚林 胡德聪 刘琼
机构地区 长江大学化学与环境工程学院 化学工业出版社 华中科技大学化学系
出处 《化学与生物工程》 CAS 2004年第4期10-12,共3页 Chemistry & Bioengineering
关键词 硒 信号传导 氧化还原 selenium signal transduction redox reaction
分类号 Q507 [生物学—生物化学] Q584 [生物学—生物化学]
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参考文献20

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二级参考文献3

共引文献8

同被引文献26

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化学与生物工程
2004年 第4期

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