血清NO、IL-6及IL-8与急性高原病的关系研究

Studies of Relationship Between Serum NO, IL-6, IL-8 and Acute High Altitude Disease

目的 :了解血清一氧化氮 (Nitricoxide ,NO)、白介素 - 6 (Interleuk - 6 ,IL - 6 )及白介素 - 8(Interleuk - 8,IL - 8)与急性高原病 (Acutehighaltitudediseaes ,AHAD)及NO与IL -6、IL - 8之间的关系。方法 :将 4 7例AHAD患者随机分为两组 ,一组为常规药物治疗组 (2 3例 ) ,另一组为NO治疗组 (2 4例 )。常规药物治疗组给予吸氧、氨茶碱、地塞米松、速尿等药物常规治疗 ,NO治疗组仅给予吸入由海拔 36 5 8m高度的空气平衡的 1 0 ppm的NO气体 ,每天2次 ,上午、下午各 1h ,并对两组AHAD患者治疗前后的血清NO(NO以其代谢终产物NO3-和NO2 - 表示 )、IL - 6及IL - 8含量进行观察比较。结果 :两组治疗后的血清IL - 6及IL - 8含量均显著低于治疗前 ,NO含量则均显著高于治疗前 (NO治疗组P <0 .0 0 1 ,常规药物治疗组P <0 .0 5～ 0 .0 1 )。且两组治疗后的血清NO、IL - 6及IL - 8含量亦具有显著性差异 (P <0 .0 5 )。结论 :血清NO、IL - 6及IL - 8与AHAD有着密切关系 ,NO能抑制AHAD患者IL -6及IL - 8的分泌 。

Objective: To find out the relationship between serum NO (nitric oxide, NO), IL-6 (interleuk-6, IL-6), IL-8 (interleuk-8, IL-8) and Acute high altitude disease (AHAD), and the relationship between serum NO and IL-6, IL-8.Method:Randomly divide 47 AHAD patients into two groups, one is traditional medicine treating group and the other is NO treating group. The former had been given traditional treatment by oxygen etc, while the later had been given 10ppm NO,2/day (1h at Am. and Pm. Respectively). NO had been balanced by air at 3658M altitude. The level of serum NO (NO was denoted by its metabolic products, NO 3 - and NO 2 -), IL-6 and IL-8 were compared before and after treatment in two groups. Results: Serum IL-6 and IL-8 were remarkably decreased after treatment in two groups, while serum NO was remarkably increased ( P <0.001 in NO treating group, P <0.05～0.01 in traditional medicine treating group). There is distinct difference between the level of serum NO and IL-6, IL-8 of the two groups after treatment( P <0.05).Conclusion:Serum NO and IL-6, IL-8 has close correlation with AHAD. NO can inhibit the secretion of IL-6 and IL-8 in AHAD patients and has active effect to patient rehabilitation.