妊高征病人血清β-hCG及血管内皮生长因子的测定及临床意义

Clinical significance of VEGF and β-hCG in serum of normal pregnancies and patients with pregnancy induced hypertension.

目的 为探讨血清血管内皮生长因子 (VEGF)、人绒毛膜促性腺激素 (β -hCG)在妊娠高血压综合征 (妊高征 )发病中的作用及二者在妊高征发病中的相互关系。方法 :采用放射免疫方法测定 30例正常妊娠妇女 (对照组 )及 35例妊高征(轻度 8例、中度 14例及重度 13例 )患者 (妊高征组 )分娩前及新生儿脐静脉血VEGF与 β -hCG水平。结果 :(1)妊高征组孕妇血VEGF为 (15 .6 94± 2 .187) (μg/L) ,正常妊娠组孕妇血VEGF为 (18.80 3± 2 .0 5 0 ) (μg/L) ,妊高征组与正常妊娠组比较 ,差异有显著性 (P <0 .0 5 )。轻、中度及重度妊高征患者血VEGF分别为 (16 .35 9± 0 .389) (μg/L)、(14 .5 6 2± 0 .6 5 3) (μg/L) ;VEGF水平与妊高征病情严重程度呈负相关 (r=- 0 .35 2 ,P <0 .0 5 )。 (2 )妊高征患者血 β -hCG为 (186 0 .35 7± 36 .4 36 )(mIU/ml)明显高于正常妊娠组 (16 11.16 3± 6 2 .341) (mIU/ml) ,差异有显著性 (P <0 .0 5 ) ;且重度妊高征患者血 β -hCG(1985 .872± 82 .86 1) (mIU/ml)明显高于轻、中度 (176 9.5 83± 4 2 .35 2 ) (mIU/ml) (P <0 .0 5 ) ;(3)两组患者血清VEGF与 β-hCG之间存在负相关 (P <0 .0 5 ,r=- 0 .311) ;(4 )两组患者新生儿脐静脉血VEGF、β -hCG之间差异无显著性 (P >0 .

Objective: To examine the level of VEGF and β-hCG in maternal serum of normal pregnancies and patients with pregnancy induced hypertension (PIH) and to study the clinical significance and effects of them on the pathogenesis of the disease. Methods: Serum levels of VEGF and β-hCG of 30 normal pregnant women and 35 patients with PIH (mild 8, moderate 14 and severe 13) were determined by radioimmunossay. Results: (1) Serum levels of VEGF in all PIH subgroups (16.359±0.389 ) (μg/L)、(14.562±0.653)(μg/L) in mild to moderate and severe were significantly lower than the normal pregnant group(18.803±2.050)(μg/L) (Ρ<0.05 ). There is negative correlation between levels of VEGF and degrees of PIH (r=-0.352,P<0.05). (2)Serum levels of β-hCG in PIH (1860.357±36.436 )were significantly higher than the normal pregnant group (1611.163±62.341) (mIU/ml). (3) There is negative correlation between levels of VEGF and β-hCG (P<0.05, r=-0.311) in PIH and normal pregnant women. (4) There were no significance in serum levels of VEGF and β-hCG in cord blood of PIH and normal pregnant women.Conclusion: The levels of VEGF and β-hCG may be suggested the degree of PIH, they may be one of the indicator of PIH; VEGF may be correlated with β-hCG in development of PIH.