超抗原金黄色葡萄球菌肠毒素对荷瘤大鼠胃癌模型炎性介质影响的研究

Effect of superantigen SEA on the plasma levels of inflammatory mediators in mice gastric tumor

目的 研究超抗原金黄色葡萄球菌肠毒素 (SEA)对荷瘤大鼠胃癌模型炎性介质影响。方法 采用人胃癌细胞 (MGC80 -3 )皮下接种建立大鼠胃癌模型 40只 ,实验组注射SEA ,对照组注射生理盐水 ,检测大鼠体内炎性介质水平。结果 荷瘤大鼠模型SEA处理以后 ,血清IL 1β ,IL 6,IL 12 ,TNF α和内毒素水平均明显上升 ,与对照组相比差异有显著性 ,尤其以血清IL 1β内毒素水平上升明显 (P <0 .0 1)。结论 超抗原SEA可激活大量的T细胞 ,分泌多种细胞因子 ,直接或间接地杀伤肿瘤细胞。

Objective To study the effect of superantigen SEA on the plasma levels of inflammatory mediators in mice gastric tumor.Methods The subcutaneous tumor model was produced by inplating gastric tumor cell(MGC80-3).The trail group was treated with SEA and the control group was treated with normal saline.The plasma levels of inflammatory mediators were observed.Result The plasma levels of inflammatory mediators such as IL-1β,IL-6,IL-12,TNF-α,endotoxin in the SEA group was much higher than the control group.There was obvious difference between the two groups.Conclusion The SEA has an obvious antitumor effect in mice gastric tumor effect in mice gastric tumor by the excretion of inflammatory mediators.