变应性鼻炎患者血清一氧化氮水平变化及临床意义

Changes of Nitric Oxide in Serum of Patients with Allergic Rhinitis and its Clinical Significance

目的 :通过 5 6例变应性鼻炎患者血清一氧化氮 (NO)浓度的观察 ,研究内源性NO水平的变化与变应性鼻炎病理过程的关系及其临床意义。方法 :血清NO水平采用硝酸还原酶比色法测定。结果 :变应性鼻炎组血清NO水平显著高于正常对照组 (q =2 7.2 3,P <0 .0 1)及慢性鼻炎组 (q =15 .2 3,P<0 .0 1)。慢性鼻炎组与正常对照组血清NO浓度差异无显著性 (q =1.89,P >0 .0 5 )。结论 :变应性鼻炎患者血清中NO水平显著高于正常对照组及慢性鼻炎组 ,提示NO在变应性鼻炎的发病过程中可能起重要作用 ,对其机理的研究为变应性鼻炎的治疗提供新的方法。

Objective:To study the changes of endogenous nitric oxide in serum of 56 patients with allergic rhinitis and the relationship between the changes of endogenous nitric oxide and the pathology,as well as its clinical value. Methods:Nitric oxide in serum was measured by nitrate reductase. Results:The level of serum nitric oxide in allergic rhinitis group was higher than that in healthy control group(q =27.23,P< 0.01 ) and chronic rhinitis group(q =15.23,P<0.01).However,the level of serum nitric oxide had not significant difference between chronic rhinitis group and healthy control group(q =1.89,P>0.05). Conclusion:Nitric oxide maybe play an important role in pathogensis of allergic rhinitis. The study may provide a new method for the therapy of allergic rhinitis.