期刊文献+

MCS+血细胞分离机单一供者血小板采集质量及冲红原因 被引量:3

Analysis on the concentrating quality and on cause of RBC spill-over concentrating for single donor platelet with MCS+ blood cell separator
下载PDF
导出
摘要 目的分析MCS+血细胞分离机单一供者血小板(SDP)的采集质量与冲红原因。方法以MCS+采集196人份SDP,以KX-21血细胞分析仪并比较SDP成品中血小板(plt)含量、白细胞(WBC)污染量、红细胞(RBC)污染量、采前红细胞压积(Hct)及采前平均红细胞体积(MCV)等参数。结果196人份SDP成品中19人份SDP发生冲红现象,plt平均含量为(3.64±0.81)×1011袋,WBC、RBC污染量符合质量控制要求,分别占90.82%和33.16%。冲红组与未冲红组比较显示SDP成品中plt、采前Hct差异无显著性,而WBC污染、RBC污染及采前MCV差异有显著性(分别P<0.001,P<0.01,P<0.001)。结论MCS+采集的SDP其plt含量完全符合质量控制标准WBC严重污染几乎与冲红现象同步。采前MCV是导致冲红与否的关键,在其他指标符合要求的前提下,采前MCV≥88fL将可杜绝冲红现象的发生。 Objective To analyze the quality and study the cause of RBC spill-over in concentrating single donor platelet with MCS+ blood cell separator.Methods The 196 doses of SDP products collected with MCS+ and the parameters of platelet (plt) yield, white blood cell (WBC) contamination, red blood cell (RBC) contamination, pre-haematocrit (Hct) and pre-mean-cell-volume (MCV) counted with KX-21 blood cell analyzer were compared. Results Of all 196 doses of SDP, the RBC spill-over was 19 doses of SDP, the plt average yield was (3.64±0.81)×1011,the rates of WBC and RBC contamination within the quality control were 90.82% and 33.16% respectively. Comparing the group of RBC spill-over with the group of no RBC spill-over, it was found that the levels of plt yield and pre-Hct were variances insignificantly while the WBC contamination and the RBC contamination and the pre-MCV were different significantly(P<0.001,P<0.01,P<0.001,correspondingly).Conclusion The plt yield of SDP collected with MCS+ is fully met the criteria of quality control; the severe WBC contamination and RBC spill-over are almost happened synchronously. Pre-MCV is the key causing RBC spill-over, in the condition of other parameters meeting the requirement, the RBC spill-over could be prevented while the level of pre-MCV≥88fL.
出处 《实用医药杂志》 2004年第8期740-742,共3页 Practical Journal of Medicine & Pharmacy
关键词 MCS+血细胞分离机 单一供者血小板/采集 质量分析 MCS+ blood cell separator Single donor platelet/collection Quality analysis
  • 相关文献

参考文献5

  • 1[1]Moog R, Muller N. White cell reduction during plateletpheresis: a comparison of three blood cell separators. Transfusion,1999,39(6):572
  • 2周小玉,汪承亚,陈亦江,周源.体外循环手术中血小板单采对血液的保护作用[J].中国输血杂志,2003,16(1):3-6. 被引量:16
  • 3[5]Moog R. Fujisurge technique and continuous in-line filtration to improve the quality of single donor platelet concentrates. J Clin Apheresis, 2002, 17(4): 199
  • 4[6]Wadhwa M,Krailadsiri P, Dilger P, et al. Cytokine levels as performance indicators for white blood cell reduction of platelet concentrates. Vox Sang, 2002, 83(2): 125
  • 5[7]Seghatchian J,Beard M,Krailadsiri P.The role of in process qualification in quality improvement of the haemonetic MCS plus leucodepleted platelet concentrate.Transfus Sci, 2000, 22(3): 165

二级参考文献4

  • 1[1]Menges J,Welters I,Wagner RM,et al.The influence of acute preoperative plasmapheresis on coagulation tests,fibrinolysis,blood loss and transfusion requirements in cardiac surgery.Eur J Cardiothorac Surg,1997,11(3):557
  • 2[2]Shulman G,Solanki DR,Hadjipavlou A.Augmented autologous transfutions in major reconstructive spine surgery.J Clin Apheresis,1998,13(2):62
  • 3[3]Rubens FD,Fergusson D,Wells PS,et al.Platelet-rich plasmapheresis in cardiac surgery:a meta-analysis of the effect on transfusion requirements.J Thorac Cardiovasc Surg,1998,116(4):641
  • 4[4]Christenson JT,Reuse J,Badel P,et al.Plateletpheresis before redo CABG diminishes excessive blood transfusion.Ann Thorac Surg,1996,62(5):1373

共引文献15

同被引文献14

引证文献3

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部